Endocrine Pathology

SUPPLEMENTAL IMAGE DATABASE

Pituitary

Normal structure and function

• The mixed population of the pituitary anterior lobe by H&E stain (eosinophils, basophils, chromophobes).
• Secretory granules, electron micrograph
• Prolactin-producing cells. Immunostain

Hypopituitrism

• Partial infarction of anterior lobe
• Adiposo-genital dystrophy (Frohlich disease)

Hyperpituitrism: gigantism and acromegaly

• Acromegaly

Cushing disease

• Adenoma composed of basophilic cells (H&E) in Cushing disease.
• Same case with immunostaining for ACTH in adenoma.
• Cushing disease: Moonface with plethora (too many red blood cells).

Clinical features of pituitary adenoma

• Advanced Cushing disease
• Effects of pituitary macroadenoma
• Similar case in vivo
• Autopsy case. Unoperated macroadenoma of pituitary.
• MRI scan of macroadenoma, frontal view.
• MRI scan of macroadenoma: sagittal view.
• Pituitary adenoma emerging from sella
• Huge pituitary adenoma

Craniopharyngioma

• Suprasellar craniopharyngioma. Gross view
• Same case, micro

Thyroid

Thyroglossal duct cyst

• Patient, gross
• After resection, gross

Graves disease

• A list of major clinical manifestations of Graves disease (fig. 21-11, page 605, Essential Pathology).
• Diffuse toxic goiter of Graves disease, gross
• Enfermedad de Graves. Micro.
• Diffuse hyperplasia of the thyroid in Graves disease

Hypothyroidism

• A list of major clinical manifestations of hypothyroidism (Fig. 21-8, page 602, Essential Pathology).
• Myxedema
• Pretibial myxedema

Hashimoto thyroiditis

• Struma lymphomatosa in Hashimoto thyroiditis, gross
• Lymphocytic infiltrate in the thyroid, micro
• Lymphocytic infiltrate in Hashimoto thyroiditis, micro

Nodular, non-toxic goiter

• Bocio No Tóxico. Macro
• Non-toxic goiter, gross
• Mixed large and small follicles, micro

Thyroid tumors

• Follicular adenoma, gross
• Follicular adenoma, micro
• Follicular adenoma, micro
• Papillary carcinoma, gross
• Papillary carcinoma, micro
• Follicular carcinoma, micro

Adrenal

Adrenocortical insufficiency

• Waterhouse Friderichsen syndrome.
  • WF en un niño con Meningitis Meningococcica
  • Hemorrhagic adrenal, gross
• Addison disease, atrophic adrenal, gross

Cushing adrenal hypercorticism

• Fascies de Luna. Antes y despues de Tratamiento.
• Abdominal striae in a patient with trucal obesity in Cushing syndrome.
• Hiperplasia Cortico Suprarenal. Macro. Sindrome de Cushing.

Congenital adrenal hyperplasia (CAH)

• Clitoral enlargement and labial fusion
• Gross - hyperplastic adrenals and poorly developed ovaries

Conn syndrome (primary aldosteronism)

• Adrenal cortical adenoma, gross
• Adrenal cortex in Conn syndrome, micro.

Pheochromocytoma

• Catecholamine-secreting pheochromocytoma of adrenal medulla gross
• Pheochromocytoma, micro

Neuroblastoma

• Large retroperitoneal neuroblastoma in a child, gross
• Neuroblastoma, micro
• Neuroblastoma. Micro. Rosetas.

Parathyroid

• Normal gross appearance of parathyroids
• Parathyroid chief cells, micro.
• Oxyphil cells of the parathyroid, micro

Primary hyperparathyroidism

• Hiperparatiroidismo.Panorámica
• Parathyroid adenoma, gross.
• Adenomatous chief cells, micro
• Cystic bone lesions in hyperparathyroidism, gross
• Hiperparatiroidismo Primario. Lesiones oseas. Macro.
• Osteitis fibrosa cystica, micro

Parathyroid hyperplasia

• primary parathyroid hyperplasia.
• Water-clear (German, Wasserhelle) cell hyperplasia

Secondary parathyroid hyperplasia in chronic renal disease

• Relationships between Ca, vitamin D metabolites
• Metastatic calcification of the heart
• Metastatic calcification of the heart, micro