Bone and Arthritis

SUPPLEMENTAL IMAGE DATABASE

Bone formation and non-neoplastic bone diseases

Endochondral bone formation

• Anatomic regions of the long bone, diagram
• Levels of the growth plate (epiphyseal plate),diagram
• Matrix vesicle in Phase 1 of calcification
• Matrix vesicle, Phase 2 of calcification

Membranous bone formation

• Non-decalcified section of the surface of an endostealbone spicule, micro
• Matrix vesicles within osteoid

Scurvy

Rickets and osteomalacia

• Diagram listing clinical features of rickets
• Low magnification microscopic image of an enlargedcostochondral junction in rickets.
• Non-calcified, hypertrophied growth plate inrickets, micro
• Osteomalacia in medullary bone, non-decalcifiedsection, micro.

Osteoporosis

• Normal medullary bone, non-decalcified microscopy
• Osteoporotic medullary bone, non-decalcifiedmicro

Paget disease

• Dense bone trabeculae in Paget disease, non-decalcifiedmicroscopy
• Enormous osteoclast in Pagetic bone, undecalcifiedmicroscopy

Achondroplastic dwarfism

• Hemisected tibia in achondroplasia, gross
• Disordered growth plate and metaphysis in achondroplasia,micro.

Osteogenesis imperfecta (0.I.)

• X-ray of newborn with O.I.
• Non-decalcified microscopic section of rib incongenital 0.I.

Osteopetrosis

• X-ray of the very dense long bones of a childwith congenital osteopetrosis
• Bone-within-a-bone appearance of a sagitallysectioned humerus in congenital osteopetrosis, gross
• Microscopic cross-section of rib in osteopetrosis

Myositis ossificans (fibrous dysplasia ossificans progressiva)

Hypertrophic osteoarthropathy

• Clubbing of the terminal phalanxes

Bone infarct (aseptic necrosis of bone, tibia and femur)

Osteomyelitis

• Hemisected lower extremity
• Reactive perioseal overgrowth of bone

Bone tumors

• Fibrous dysplasia

  • X-ray of femur in a 10 year old female
  • Typical microscopic appearance of trabecularbone in fibrous dysplasia

• Giant cell tumor of bone

  • Giant cell tumor
  • Multiple, osteoclast-like giant cells

• Osteosarcoma

  • Codman triangle
  • Atypical osteoblastic cells

• Chondrosarcoma

  • Characteristic gross appearance of chondrosarcoma
  • Atypical chondrocytes

Arthritis

Gout

• Acute gout
• Chalky tophoceous urate deposits
• Radial clusters of acellular monosodium uratecrystals

Septic arthritis

Osteoarthritis

Rheumatoid arthritis (RA)

• Radiograph of a hand in late-stage rheumatoidarthritis

Giant cell tumor of tendon sheath

• Giant cell tumor
• Giant cells

Synovial sarcoma (synovioma)

• Synovial sarcoma