Cell Injury

Coordinator: Ivan Damjanov, M.D., Ph.D.

SUPPLEMENTAL IMAGE DATABASE

REVERSIBLE ACUTE CELL INJURY:

• Hinchazón Hidrópica o vacuolar
• Morphological changes of cellular organelles in response to injury
• Cytoplasmic changes
  • Mitochondria
  • RER
  • SER
  • Cytoskeleton
  • Cell membrane
  • Nuclear changes

ADAPTATIONS:

• Reactions to persistent stress
  • Atrophy
  • Hypertrophy
  • Hyperplasia
  • Combined hypertophy and hyperplasia
  • Metaplasia
  • Dysplasia
  • Intracellular storage
    • Glycogen
    • Lipid
    • Iron
    • Pigments
    • Lysosomal storage
    • Lipofuscin

IRREVERSIBLE CELL INJURY:

• Cell death (morphology)
  • Necrosis
  • Pyknosis
  • Karyolysis
  • Karyorrhexis
  • ApoptosisHepatitis viral
• Pathogenesis of irreversible cell injury
  • Hypoxic cell injury
    • Oxygen radicals
    • Role of iron in cell injury
  • Cell killing by viruses
  • Outcome of cell death
    • Calcification
• Necrosis (morphology at the organ/tissue level)
  • Coagulative necrosis
  • Gangrena gaseosa
  • Liquefactive necrosis
  • Necrosis grasa de Pancreas (macro)
  • Caseous necrosis
  • Fibrinoid necrosis

AGING

• Theories of aging
• Genetic aspects of aging

DEATH