Immunopathology

Coordinator: Jim Fishback, M.D.

SUPPLEMENTAL IMAGE DATABASE

Cellular components of the immune response

• Lymphocyte subsets
  • Flow cytometer, diagram
  • Peripheral blood lymphocytes
• mast cell, bone marrow, Wright stain
• mast cell, electron micrograph (note granules)
• mononuclear phagocytes
  • circulating monocyte
  • Langerhans cells, skin
  • pulmonary macrophages
  • Tingible body macrophage, lymph follicle

Human major histocompatibility complex (Fig 4-2, page 70)
Immunologically mediated tissue injury

• Type I hypersensitivity
  • asthma, smooth muscle hypertrophy, bronchioles
  • asthma, mucus plugging, high power
  • asthma, eosinophils in peri-bronchial tissue
• Type II hypersensitivity
  • Hashimoto thyroiditis
    • Hashimoto thyroiditis, gross
    • Hashimoto thyroiditis, H/E
    • Hashimoto thyroiditis, microsomal antibody, immunofluorescence
    • Hashimoto thyroiditis, thyroglobulin antibody, immunofluorescence
  • Pemphigus
    • Pemphigus, patient photo
    • Pemphigus, H/E, skin, low power
    • Pemphigus, skin, H/E, high power
    • Pemphigus, skin, direct immunofluorescence, IgG
  • Rheumatic heart disease
    • Chest x-ray, valve replacements, rheumatic heart disease
    • Chronic rheumatic valvulitis, gross
    • Chronic rheumatic mitral and aortic stenosis, with dilation
• Type III hypersensitivity
  • Systemic Lupus Erythematosus
    • SLE, malar rash
    • Anti-nuclear antibody (ANA) cell preparation, immunofluorescence
    • LE cell preparation
  • Polyarteritis nodosa (page 264; page 487, big Rubin)
• Type IV hypersensitivity
  • Poison Ivy, (contact dermatitis);
  • Tuberculin skin test (purified protein derivitive, PPD)

Immune reactions to transplanted organs and tissues

• Host vs. graft reactions
  • Artery, acute rejection, transplanted kidney, H/E x100
• Graft vs. host reactions
  • Acute GVH
  • Chronic GVH

Immunodeficiency disease

• Deficiencies of antibody-producing cells (B cells)
  • X-linked hypogammaglobulinemia
  • Common variable immunodeficiency
  • Selective IgA deficiency
• Deficiencies of cell-mediated immunity (T cells)
  • DiGeorge syndrome
  • Chronic mucocutaneous candidiasis
• Combined T-cell and B-cell deficiencies
  • Severe combined immunodeficiency (SCID)
  • Wiscott-Aldrich syndrome
  • HIV infection
    • Life cycle of HIV (see also Figure 4-20, page 127, big Rubin)
    • HIV replication, the movie

Autoimmunity

• SLE
  • Lupus tutorial, University of Utah
• Progressive systemic sclerosis
  • Skin, scleroderma, H/E x10
  • scleroderma, with Raynaud phenomenon and auto-amputation
  • scleroderma, esophagus, fibrosis, trichrome stain for collagen
• Dermatomyositis
  • polymyositis/dermatomyositis, H/E, skeletal muscle