Mucus plugging, bronchiole, asthma
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One of the response of the bronchiole in asthma is the metaplastic proliferation of goblet or mucus-producing cells. Often, this results in the over-production of mucus, which plugs otherwise severely broncho-constricted bronchioles. One sometimes sees eosinophils within the mucus, occasionally with crystallized eosinophilic granules (Charcot-Leyden crystals).