Polyarteritis nodosa
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Polyarteritis affects small to medium-sized arteries. It is associated with hepatitis B, and circulating immune complexes are thought to play a role, although, like many immunologic diseases, this remains speculative. Clinically, any artery can be affected, and thrombosis may occur. Symptoms are related to the organ involved, although patients also have constitutional symptoms, like malaise, fever, and weight loss. Histologically, fibrinoid necrosis is prominent, with a variable perivascular infiltrate of lymphocytes and polymorphs. (page 264; page 487, big Rubin).