UNSW Embryology

Development of the Head and Neck

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DEVELOPMENTAL ABNORMALITIES

Cleft Palate
Cleft Lip
Pierre Robin Syndrome

The malformations CLEFT LIP and palate and PIERRE ROBIN SYNDROME during the lecture series and demonstration materials will be provided during the practical class.

Cleft lip and palate develop between the 4th and 8th week of gestation and is dominated by changes resulting in the formation of the nose. Palatal development occurs between the 7th and 12th week of gestation and is divided into the formation of the primary palate (prolabium), premaxilla and cartilaginous septum) and formation of the secondary palate (hard and soft palate).

In the treatment and repair of cleft lip the following results are hopefully achieved:

(i) a symmetrical lip

(ii) a natural appearing philtral ridge and dimple

(iii) negligible scarring

(iv) a symmetrical nose and restoration of the nostril floor.

The major objectives of the repair of the cleft palate includes construction of a competent, functioning and watertight valve at the junction of the soft palate and pharynx; repair is performed early enough to allow the child to begin speech with a functioning velopharyngeal valve. Presentation of normal hearing must also be maintained along with normal development and bone growth in the central facial region along with a functional and attractive dentition.

Cleft Palate

  • International Classification of Diseases code 749.0
  • Australian national rate (1982-1992) 4.8 - 6 /10,000 births.
  • Of 1,530 infants 5.5% were stillborn and 11.5% liveborn died during neonatal period.
  • slightly more common in twin births than singleton.
    • Congenital Malformations Australia 1981-1992 P. Lancaster and E. Pedisich ISSN 1321-8352

OMIM Database Entry- Orofacial Cleft with or without cleft palate (about this entry)

Cleft Lip

  • International Classification of Diseases code 749.1 for isolated cleft lip and 749.2 for cleft lip with cleft palate.
  • Australian national rate (1982-1992) 8.1 - 9.9 /10,000 births.
  • Of 2,465 infants 6.2% were stillborn and 7.8% liveborn died during neonatal period.
  • rate similar in singleton and twin births.
    • Congenital Malformations Australia 1981-1992 P. Lancaster and E. Pedisich ISSN 1321-8352

 

OMIM Database Entry- Cleft Lip List (about this entry)

Pierre Robin Syndrome

OMIM Database Entry- Pierre Robin Syndrome (about this entry)

OMIM Database Entry- PIERRE ROBIN SYNDROME WITH CONGENITAL HEART MALFORMATION AND CLUBFOOT (about this entry)

OMIM Database Entry- PIERRE ROBIN SYNDROME AND OLIGODACTYLY

OMIM Database Entry- Pierre Robin List 23 entries found, searching for "pierre robin syndrome" (about this entry)

OMIM Database Entry- EAR MALFORMATION

Self Assessment Questions

Australian Statistics 1981-1992

About Data

Data shown as a % of all Major Abnormalities based upon published statistics using the same groupings as CMA 81-92.

You can also see:

all the statistical data as graphs

List of all Minor Abnormalities

PubMed Database

Online Medline Database PubMed- Medline

National Library of Medicine (US) search service to access the 9 million citations in MEDLINE and Pre-MEDLINE (with links to participating on-line journals), and other related databases.

Internet Search this database or use the form below with the keyword or related topics. You can also restrict to reviews or by date published.

  • Note: This database is an external link, not accessible from some computers in the School of Anatomy.
  • A Selected List of References from March 1999 search results for and is available for these computers.

Search Field: Mode:

PubMed

Respiratory Terms

About Notes

  • Lecture notes from the Anat 3311 1997 Science Embryology course compiled and written by Dr Mark Hill. Some notes derived from historic class notes.
  • Note Links to OMIM Entries are copies of originals for computers without internet access. Computers with internet access can directly access the database.

Links

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m.hill@unsw.edu.au
Date Last Modified: 19/3/99
This site maintained by Dr M. Hill