Pulmonary eosinophilic granuloma:
Chapter: 12
(also referred to as pulmonary histiocytosis X, or Langerhans cell granulomatosis) This is a proliferative disorder of histiocytes characterized by patchy nodular interstitial lesions. Clinically patients may present with cough and dyspnea, or they may be asymptomatic. Radiographically, there are multiple nodules distributed throughout both lungs. Histologically the infiltrate is composed of a variable mixture of histiocytes (Langerhans cells) and eosinophils, as well as occasional plasma cells and lymphocytes. Older lesions show a stellate pattern of fibrosis. Electron microscopy of Langerhans cells demonstrates the characteristic Birbeck granules.
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