Eosinophil
Chapter: 2
These cells are easily distinguished by their relatively large granules that take up red dye in routine stains. Eosinophils are particularly prevalent in allergic reactions and parasitic infections, where their numbers can be increased in both the circulation and at the site of inflammation. The granules of eosinophils, which are characterized by electron-dense bar-like bodies ultrastructurally, contain unique basic proteins that are toxic to certain parasites. They also contain peroxidase, acid phosphatase, and cationic major basic protein. Eosinophils respond chemotactically to a cytokine produced by stimulated mast cells (eosinophil chemotactic factor).
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