UNSW Embryology

WEEK 1 Development

Page 1 | 2 | 3 | 4 | 5 | WWW

Page LinksIntroductionReading Computer Activities ObjectivesLearning activities Development Overview TermsReferencesAbout Notes

Page 2 | Abnormalities | OMIM | Questions | Medline
Page 3 | Fertilization Notes
Page 4 | Blastocyst Dev
Page 5 | In vitro fertilization
Text only page | WWW Links |

Introduction These notes cover the first week of development, including the fertilization process, morula and blastocyst development, and transport in uterine tube.

Reading Human Embryology (2nd ed.) Larson Ch1 p1-32 The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Before we Are Born (5th ed.) Moore and Persaud Ch Essentials of Human Embryology Larson Ch1 p1-16 Human Embryology Fitzgerald and Fitzgerald Additional References- Selected, Search PubMed- Medline

Computer Activities UNSW Embryology: Embryo Images Unit: Unit: Early cell Populations Video BBC series The Human Body, Episode 2 available commercially as a book by Anthony Smith, video, or CD Rom short sample video available from ABC (needs realvideo) "Ancient" Japanese video on fertilization.

Objectives Understand the mechanisms of gamete formation. Understand the mechanisms of cell division. Describe the differences between mitosis and meiosis. Understand the mechanisms of fertilization. Describe the cleavage of the zygote. Describe the processes in formation of the blastocyst. Summarize the events of the first week of development.

Learning activities Discuss the similarities and differences between fertilization processes in different vertebrates. Discuss the morphological and chemical changes which occur following fertilization. Discuss the anatomical structures involved in fertilization and development of the embryo. Discuss the development of in vitro fertilization technologies. Work through the individual separate notes relating to this topic Gametogenesis Fertilization Cell Division Work through the Hypercell Program sections on Cell division Fertilization

Development Overview		These images reproduced with permission from Dr S. J. DiMarzo (WWW Page)
Mature Human Egg large egg in comparison to surrounding granulosa cells.	Fertilized Human Zygote male and female nuclei fusing in centre of cell. 2 pronuclei on right.	4 Cell Human Embryo the embryo does not increased in size but divides the existing cytoplasm.

References Selected Lists of References from PubMed March 1999 search results are available for School of Anatomy computers without internet access. Computers with internet access can search from either Page 2 or PubMed Internet Access Selected Research Articles and Reviews Fertilization "fertilization/review" "fertilization/polyspermy" "acrosome reaction/2years" "acrosome/2years" "fertilization/meiosis" "fertilization/polyspermy" ZP1, ZP2, ZP3 Gupta- Human zona pellucida glycoproteins: characterization using antibodies against recombinant non-human primate ZP1, ZP2 and ZP3. "cortical reaction" Raz- Mechanisms leading to cortical reaction in the mammalian egg. "polar body"

WEEK 1 Development Terms acrosome- blastocyst- fertilization- flagella- meiosis- mitosis- oocyte- polar body- sperm- Xist- X inactivation- ZP1- ZP2- ZP3- zona pellucida- zygote-

About Notes

• These lecture notes from the Embryology course compiled and written by Dr Mark Hill.
• Note Links to PubMed Medline Entries are copies of originals for computers without internet access. Computers with internet access can directly access the database.
• Note that reference lists are only relevant to the date that the original search was carried out.

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m.hill@unsw.edu.au
Date Last Modified: 19/3/99
This site maintained by Dr M. Hill