Reed-Sternberg cell
Chapter: 20b
The pathognomonic malignant cell in Hodgkin disease is a Reed-Sternberg cell. The cell of origin remains controversial, but currently thought to most likely by an activated or progenitor lymphoid cell. The classic Reed-Sternberg cell is a large binucleate cell with mirror-image nuclei containing large, eosinophilic nucleoli ("owl's eye").