Langerhans cell:
Chapter: 12
Refers to the diagnostic cell seen in eosinophilic granuloma (Histiocytosis X). This cell is a large histiocyte containing a bland, folded or indented nucleus, an inconspicuous nucleolus, and abundant eosinophilic cytoplasm with indistinct cell borders. In active lesions, Langerhans cells are numerous and occur in clusters. These cells stain positively with S100 protein stain (an immunoperoxidase stain).
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