Cushing syndrome
Chapter: 21
Clinically similar to Cushing disease, but is caused by primary overproduction of adrenal cortical glucocorticoid hormones, due to adenoma, hyperplasia or carcinoma of the adrenal cortex. Ectopic production of ACTH e.g., in pulmonary carcinoids may play a role, and very often iatrogenic Cushing syndrome comes from prolonged treatment with corticosteroids, particularly treatment of autoimmune diseases.In both Cushing disease and Cushing syndrome, one may see moon face, buffalo hump, muscle atrophy, hyperglycemia, elevated red blood cell count (hyperglobulia) as well as hypernatremia and hypokalemia.
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