Chromosomal abnormality
Chapter: 20b
The presence of a non-random cytogenetic abnormality. In hematogy, some subtypes of myelodysplasia, leukemia and lymphoma are associated with characteristic cytogenetic abnormalities, some of which are important for diagnosis as well as predicting the likelihood of achieving complete remission and survival. For example, 65% of cases of ALL have a cytogenetic abnormality, with hyperdiploidy being the most common and known to be a favorable prognostic indicator.