acute rejection
Chapter: 4
Acute rejection occurs in the first weeks or months following solid organ transplantation. It is characterized histologically by: 1) edema, 2) interstitial infiltration of lymphocytes and macrophages, and 3) focal necrosis. The most severe form may also show fibrinoid necrosis of vessel walls, perhaps with thrombosis, similar in this respect to hyperacute rejection. Acute rejection involves both humoral and cell-mediated immune reactions.