Myeloproliferative disorder
Chapter: 20b
Clonal stem cell disorder characterized by proliferation of one or more cell lines, which classically include 4 closely related disease entities which have overlapping clinical and morphologic features. Pancellular bone marrow hyperplasia, variable bone marrow fibrosis, leukocytosis, thrombocytosis and splenomegaly may be present, in variable degrees, in most patients. The four chronic myeloproliferative disorders are listed below, with a few notable features of each disease.