Mycosis fungoides
Chapter: 20b
T cell lymphoma primary to the skin, which is characterized by several clinical stages which include patch, plaque and tumor stage. If the disease manifests a leukemic phase, it produces generalized erythroderma, and is called Sezary syndrome. The cells of mycosis fungoides and Sezary syndrome are malignant T cells which have convoluted, cerebriform nuclei and hyperchromsia. In the skin, the malignant cells display epidermatropism (migration up into the epidermis), and form characteristic small epidermal aggregates termed Pautrier microabcesses.