Megaloblastic maturation:
Chapter: 20a
Abnormal cellular maturation which shows nuclear-cytoplasmic dissynchrony. In folate/B12 deficiency, the nuclear maturation lags behind the cytoplasmic maturation due to impaired DNA synthesis. This results in cells of abnormally large size with an immature chromatin pattern. Peripheral smear shows macrocytes, teardrops, ovalocytes and hypersegmented neutrophils in cases of megaloblastic anemia due to folate/B12 deficiency.
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