Kallikrein
Chapter: 2
The serine proteinase that is generated by activated Hageman factor from the inactive plasma protein, prekallikrein. It cleaves the precursor plasma proteins, called kininogens, to form the proinflammatory kinins, e.g., bradykinin. It also can activate plasminogen to yield plasmin. Kallikrein has direct chemotactic activity and also has the capacity to cleave C5 to C5a, which is an exceptionally potent chemotactic agent.