Hydatidiform mole
Chapter: 18
A gestational trophoblastic disorder in which the placenta have has grossly swollen chorionic villi, resembling a bunch of grapes, with varying degrees of trophoblastic proliferation and absence of embryo. Most complete moles are homozygous, XX 46 and all the chromosomes are of paternal origin. Patients with complete mole present during the second trimester of pregnancy with abnormal uterine bleeding, excessive uterine enlargement and high serum human chorionic gonadotropin concentration. The most important complication is the development of choriocarcinoma.