anaphylaxis
Chapter: 4
Anaphylaxis is a clinical condition that occurs when an allergen binds to specific IgE on mast cells, causing the release of histamine and other vasoactive amines. The anaphylatoxins, C3a and C5a, are also involved. This causes bronchoconstriction, which leads clinically to severe wheezing, respiratory distress, and ultimately, death. Urticaria (hives) can also occur. Anaphylaxis can only be reversed by the immediate administration of epinephrine (adrenaline), anti-histamines, bronchodilators, and systemic steroids.
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