Agnogenic myeloid metaplasia
Chapter: 20b
Agnogenic myeloid metaplasia is characterized by pancellular bone marrow hyperplasia, bone marrow fibrosis and extramedullary hematopoiesis with marked splenomegaly. Peripheral blood shows leukoerythroblastosis and anisopoikilocytosis with teardrop red blood cells. Leukemic conversion occurs in 15-20%, and the median 5 year survival is 3-4 years. CML is characterized by bone marrow granulocytic hyperplasia, marked leukocytosis with basophilia and the presence of the Philadelphia chromosome. The disease often has a stable (chronic) phase which progresses to an accelerated phase, and may then develop blast crisis. Leukemic conversion occurs in 70%, and the median 5 year survival is 3-4 years. The prognosis and outcome of CML is improving with the use of bone marrow transplantation.