Aspergillus, lung, photomicrograph, GMS silver stain
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The GMS stain impregnates the hyphae with silver, rendering them black under the light microscope. Aspergillus spp.typically branch at acute angles and have septated hyphae. Other species besides Aspergillus can have this appearance, so culture must be done in order to make a specific diagnosis. This has some prognostic significance, since Aspergillus is quite resistant to therapy with Amphotericin B.