At the conclusion of this unit, the student will be able to ...

1. Review normal hematopoiesis. Desribe the normal components of bone marrow and discuss the clinical impact of failure of each component.

2. Define acute and chronic leukemia. Know the clinical features, peripheral blood and bone marrow findings, and diagnostic techniques used to arrive at a correct diagnosis in a new leukemia.

3. Know the FAB classification for ALL and AML. List one critical feature of each subtype. Be familiar with the clinicopathologic features which are important indicators of prognosis in ALL.

4. Discuss etiologic factors in the pathogenesis of leukemia. Discuss the significance of chromosomal abnormalities in pathogenesis, diagnosis and prognosis of leukemia.

5. List the 4 chronic myeloproliferative disorders, and discuss the common clinical, laboratory and morphologic features of this group of disorders.

6. For each of the 4 myeloproliferative disorders, discuss the most important clinicopathologic characteristics which allow for a correct diagnosis.

7. Discuss leukemoid reactions and how they are distinguished from CML.

8. Discuss the clinical course of a patient with CML. Discuss the concept of accelerated phase and blast crisis in relation to patients with CML.

9. Define myelodysplastic syndrome. Be aware of the FAB classification and what features form the basis for this classification. Discuss the main clinical features, therapy and prognosis for this group of disorders.

10. Discuss reactive lymphoid hyperplasia. List 6 common etiologies for reactive lymphadenapathy. Know the clinico-pathologic features of cat scratch disease and toxoplasmosis.

11. Define malignant lymphoma and discuss the major division of lymphoma into non-Hodgkin lymphoma and Hodgkin disease. Contrast and compare the clinical and histologic features of these 2 broad groups of disease.

12. Define Hodgkin disease. Discuss the pathogenesis, clinical presentation, histologic hallmarks, diagnostic methods and prognosis of Hodgkin disease.

13. Know the 4 main subtypes of Hodgkin disease and the basis for this classification.

14. Know the clinicopathologic features of nodular sclerosis Hodgkin disease, including epidemiology, age, presenting clinical features, diagnostic work up, therapy and prognosis.

15. Be familiar with the classification of non-Hodgkin lymphoma according to the International Working Formulation. In particular, be able to place the major disease entities into a prognostic group. For example: Name the 3 high grade lymphomas.

16. Be able to discuss the clinical presentation, unique patho-physiologic features, histologic findings and classification of each of the following disease entities:
    • small lymphocytic lymphoma
    • follicular center cell lymphoma
    • diffuse large cell lymphoma
    • immunoblastic lymphoma
    • lymphoblastic lymphoma
    • Burkitt lymphoma

17. Discuss the clinical features, laboratory findings, peripheral blood and bone marrow findings, clinical course, therapy and outcome of chronic lymphocytic leukemia.

18. Discuss the clinical and histologic hallmarks of Mycosis fungoides. Define Sezary Syndrome, its clinical presentation and how it is diagnosed.

19. Discuss the clinical, laboratory and histologic features of multiple myeloma. Define plasmacytoma and monoclonal gammopathy of undetermined significance.

20. Define the listed Keywords.

21. Be able to identify, from projected slides, each of the diseases/processes in the Supplemental Image Database.