At the conclusion of this unit, the student will be able to:

1. Describe the clinical features and anatomic abnormalities in cystic renal dysplasia, autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidney disease.

2. Name the clinical abnormalities of nephrotic syndrome and trace their sequential development.

3. Name the common clinical abnormality seen with the non-inherited non-inflammatory glomerulopathies.

4. List the 4 major causes of nephrotic syndrome, in children, in adults and describe their renal pathology and clinical features.

5. List at least 6 major causes of nephritic syndrome and describe their renal pathology, major immunologic mechanisms and clinical features.

6. Describe the 5 WHO classes of lupus nephritis.

7. Describe the relationship between reflux nephropathy, ascending pyelonephritis and renal cortical scarring.

8. Describe the sequential anatomic and clinical changes which occur from acute onset to resolution of ischemic acute tubular necrosis.

9. Describe the clinical features and anatomic changes associated with drug-induced allergic interstitial nephritis, the reversible changes, the irreversible changes.

10. Outline the role of the kidney in hypertension and the effect of hypertension on the kidney.

11. Contrast and compare the major form of renal cancer in children vs. adults with respect to the gross appearance of each and clinical presentation.

12. Define the listed Keywords.

13. Be able to identify, from projected slides, each of the diseases/processes depicted in the Supplemental Image Database.