At the completion of this unit, the student will be able to ...

1. Describe the primary defect of CF.

2. Describe organ involvement of CF, and the clinical and pathological findings.

3. Name the most common screening test for CF.

4. List three major causes of acute pancreatitis.

5. List the difference between acute edematous and acute hemorrhagic pancreatitis with regard to histopathology and clinical outcome.

6. List the complications of acute pancreatitis.

7. Contrast and compare adenocarcinoma of the pancreatic head versus adenocarcinoma of the body-tail portion with regard to 1) incidence, 2) clinical presentation, 3) treatment and 4) prognosis.

8. List four pancreatic hormones and their functions.

9. List the Whipple triad of insulinoma.

10. Contrast and compare MEA-1 and -2.

11. List the diagnostic criteria of type 1(insulin-dependent) and type 2 (insulin non-dependent) diabetes.

12. Contrast and compare type 1 and type 2 diabetes in regards to 1) incidence, 2) age of onset, 3) body habitus, 4) serum glucose and insulin levels after oral glucose tolerance test, 5) concordance rate, 6) HLA antigens, 7) insulin receptor status, 8) treatment and 9) complications.

13. Define insulin resistance. List two major causes of insulin resistance.

14. Describe insulin receptor concentration and list conditions of decreased insulin receptor concentration.

15. Describe insulin receptor affinity and list conditions of decreased insulin receptor affinity.

16. Define Hemoglobin A1c (HbA1c) and describe its significance.

17. Contrast and compare coronary heart disease in diabetics versus non-diabetics.

18. Describe the clinical and laboratory findings of diabetic nephropathy. How do renal biopsy findings correspond to clinical and laboratory findings of diabetic nephropathy?

19. List three major contributing factors of diabetic foot problems.

20. Define the listed Keywords.

21. Be able to identify, from projected slides, each of the diseases/processes in the Supplemental Image Database.