At the conclusion of this unit, the student will be able to:

1. Describe the formation of bile and explain the main abnormalities that could cause jaundice.

2. Describe the principal biochemical changes typical of acute liver disease.

3. Describe the principal findings in chronic liver disease.

4. Describe the pathologic changes induced by hepatitis virus and compare the effects of hepatitis virus A, B, C.

5. Define cirrhosis and describe the most important pathologic findings in the disease.

6. Describe three forms of alcohol induced liver disease.

7. Compare predictable and nonpredictable drug induced liver disease.

8. Describe three hereditary diseases affecting the liver.

9. Discuss the pathogenesis of immunologic liver diseases and compare primary biliary cirrhosis with primary sclerosing cholangitis.

10. Describe typical infectious liver diseases caused by bacteria, protozoa and parasites.

11. Describe the morphology of gallstones and discuss their pathogenesis.

12. List the symptoms and biochemical findings caused by biliary tract disease; relate these to pathologic changes in the gallbladder and extrhepatic biliary ducts.

13. List three malignant liver tumors and compare their features.

14. Contrast and compare the features of gallbladder cancer vs. cancer of the extrahepatic bile ducts.

15. Describe the benefits and hazards of liver transplantation.

16. Define the listed keywords.

17. Be able to recognize, from projected slides, each of the diseases/processes depicted in the Supplemental Image Database.