At the conclusion of this unit, the student will be able to:

1. Distinguish obstructive from restrictive lung disease in terms of clinical presentation (including pulmonary function studies) and underlying pathology.

2. Discuss the pathogenesis, pathologic findings and clinical features of Bronchiectasis.

3. Discuss the pathogenesis, clinical manifestations, diagnostic techniques, common pathogens, pathologic features and complications of bacterial pneumonia.

4. Discuss primary and secondary tuberculosis including the pathologic features and complications.

5. List the principal pulmonary fungal pathogens: compare pulmonary histoplasmosis, coccidioidomycosis, candidiasis, aspergillosis, cryptococcosis, and blastomycosis.

6. Describe the pathology of Pneumocystis carinii pneumonia. List conditions that predispose to this disease, and describe the typical diagnostic work-up of the patient suspected of having pneumocystis pneumonia.

7. Describe the pathology of viral pneumonia and list the most frequent viruses.

8. Discuss the pathogenesis and causes of ARDS (DAD); describe the major pathologic and clinical features.

9. List the acute and chronic interstitial lung diseases; compare and contrast the clinical presentation of each.

10. Discuss AIP (Hamman-Rich Disease).

11. Discuss the clinical and pathologic features of BOOP. What conditions are associated with BOOP?

12. Describe the clinical and pathologic features of alveolar proteinosis.

13. List the diffuse pulmonary hemorrhage syndromes; discuss the clinical and pathologic features of Goodpasture Syndrome.

14. List the diseases included in the spectrum of pulmonary eosinophilia; compare and contrast simple (Loeffler), tropical, and chronic eosinophilic pneumonia.

15. Contrast and compare endogenous and exogenous lipid pneumonia.

16. Discuss the pathogenesis, pathologic and clinical features of chronic bronchitis.

17. List the types of emphysema; describe each type; discuss the pathogenesis and clinical features.

18. Discuss the pathogenesis, morphologic correlates and clinical features of asthma.

19. Discuss the major factors in the production of symptomatic pneumoconioses. List the asbestos-related diseases and describe the pathologic changes. Describe the pathologic features of silicosis and coal workers' pneumoconiosis.

20. Discuss the clinical presentation, pathogenesis, histopathology, and treatment of hypersensitivity pneumonitis.

21. Describe the clinical and pathologic features of sarcoidosis; list the most frequently involved organs.

22. Contrast and compare the clinical and pathologic features of UIP and DIP.

23. List the pulmonary disorders leading to honeycomb lung.

24. Describe the clinical and pathologic features of Wegener granulomatosis and Churg-Strauss syndrome.

25. Discuss the clinical and pathologic features of pulmonary eosinophilic granuloma (histiocytosis X).

26. List the most common factors predisposing to pulmonary thrombo-embolism. Describe the clinical symptoms, the pathology and the consequence of pulmonary embolism.

27. Discuss the pathology of pulmonary hypertension. Compare primary and secondary pulmonary hypertension.

28. Discuss the clinical course and usual treatment of lung carcinomas, including survival, sites of metastases, and common causes of death.

29. Discuss the typical clinical presentation, gross and microscopic features, and prognosis of benign and malignant mesothelioma.

30. List five paraneoplastic conditions related to lung cancer, and relate which tumor is most frequently associated with the paraneoplastic syndrome.

31. Discuss risk factors for the development of lung cancer, know the age and sex distribution.

32. List which lung tumors are central or peripheral in location, and which lung tumors are most closely associated with smoking.

33. Describe the gross and microscopic features of the more common lung tumors, to include: squamous cell carcinoma, adenocarcinoma, bronchiolo-alveolar carcinoma, small cell carcinoma, large cell carcinoma and carcinoid tumors.

34. Define the listed Keywords.

35. Be able to identify, from projected slides, each of the listed diseases/conditions in the Supplemental Image Database.