At the conclusion of this unit, the student should be able to:

1. Define atherosclerosis, discuss its epidemiology, pathogenesis and the various hypotheses of atherogenesis.

2. Describe the pathology of the early and complicated lesion of atherosclerosis and list the complications that can occur.

3. Discuss the ěrisk factorsî for atherosclerosis, the role of lipid metabolism and the effect of hypertension and diabetes mellitus.

4. Define hypertension, discuss the concept of essential hypertension and its pathogenesis and list the causes of secondary hypertension.

5. Describe the pathologic vascular changes in hypertension; the benign and malignant forms.

6. Define vasculitis, list 5 major forms of vasculitis and outline the clinical and pathologic features in each.

7. List 5 morphologically distinct aneurysms and their predominant locations.

8. Describe the clinical features, pathology and complications of a typical atherosclerotic aneurysm of the aorta.

9. Discuss the pathogenesis, pathology and risk factors of dissecting aneurysms.

10. List 2 benign and 2 malignant vascular tumors and describe their histologic features.

11. Describe the changes seen in Kaposi sarcoma and compare with those seen in bacillary angiomatosis.

12. Define varicose veins and discuss factors predisposing to their development.

13. Define the listed Keywords

14. Be able to identify, from projected slides, each of the diseases/conditions depicted in the Supplemental Image Database.